MTL - Pirates: Doflamingo Stands In the Sky - Chapter 3

God: I shall bestow the Saintess upon you.
Pope: W- wait a moment! This is a boy!
God: That is the Saintess.
Pope: ??????

And just like that, the Saintess was raised by the church for fifteen years without any questions asked…

- Description from Novelupdates

As the number one pill alchemist of the immortal world, Mu Chen had always believed that it was because he had single-mindedly focused on concocting pills that led to him to neglect disciplining his disciple. Which in turn, caused his disciple to be led astray by the seduction of devil cultivation, leading to the three realms to fall to disaster. After his rebirth, Mu Chen resolved to properly teach his disciple, give him the very best resources, earnestly love him, carry him close to his heart, teach him by way of example, and didn’t let him grow corrupt.

The story is about a man whose compulsive tendencies make it impossible for him to keep a job, and a young girl who skips school and loves insects. The two meet, come to support each other in reintegrating into society, and fall in love. There’s a problem, however: namely, the parasites in their heads.

One day, Luo Jian woke up from his sleep and found himself in a locked chamber where the door and window were all sealed. A note with a few lines written on it was tacked to the wall: “Escape from this room within an hour, otherwise, you will die.”

There is a sequel called Reincarnation Night (轮回之夜) that takes place in the same universe but has different main characters

- Description from Novelupdates